Analytical Capabilities Hub
Choose methods based on the question, sample, evidence level, and quality context.
Open pageMatch the technique family to the question: form, structure, impurity, contaminant, water, particle behavior, composition, or release testing
Analytical Capabilities by Instrument: practical triggers and decisions
Analytical Capabilities by Instrument is the right path when the project has a concrete material, analytical, quality, manufacturing, or IP decision behind it.
Triclinic scopes the work around the sample, matrix, available material, prior data, required evidence level, timeline, and whether regulated documentation is needed.
- A scientist knows a method name but needs to know whether it is screening-level, confirmatory, quantitative, or cGMP-capable.
- The decision involves form, structure, impurity, contaminant, water, particle behavior, composition, performance, or release testing.
- One method alone may not provide enough evidence for a development, CMC, quality, or IP decision.
How Triclinic Approaches Analytical Capabilities by Instrument
Triclinic selects analytical methods by the decision the data must support. Diffraction, thermal analysis, spectroscopy, microscopy, moisture analysis, chromatography, mass spectrometry, particle testing, and physical-property methods answer different questions.
Technique-focused visitors are routed to the service path that matches the decision: solid-form development, structure elucidation, contaminant investigation, cGMP testing, method development, or IP support.
- XRPD/PXRD and electron diffraction support form and structure questions.
- DSC, TGA, hot-stage microscopy, DVS, and Karl Fischer support thermal, moisture, hydrate, solvate, and physical-stability questions.
- Raman, FTIR/IR, microscopy, chromatography, LC/MS, GC/MS, elemental analysis, particle size, dissolution, and stability testing support composition, identity, impurity, contaminant, particle, and performance questions.
Analytical Instruments in our Labs
Triclinic lists cGMP and non-GMP analytical instruments and test capabilities for materials characterization, solid-state analysis, chemical identification, release testing, method development, and investigation work.
The instruments below are organized alphabetically. Each instrument or test capability links to the Analytical Techniques page that best matches the method family used to interpret the result.
Accelerated Stability
Stability studies and accelerated-condition assessments used to evaluate material behavior under defined stress conditions.
Applicable pages: Physical and Chemical Properties Analysis · Method Development, Validation, and Transfer · Manufacturing Troubleshooting
Atomic Force Microscopy
Scanning-probe microscopy for high-resolution surface topography and nanoscale imaging questions.
Applicable pages: Microscopy · cGMP Morphology · Habit and Morphology Engineering
Bulk Density
Powder-volume measurement used with tapped density and flow metrics to evaluate powder handling and settlement behavior.
Applicable pages: Bulk Powder API and Excipient Characterization · Particle Size Analysis · Manufacturing Troubleshooting
Contact Angle Measurement
Surface-wetting measurement used to compare powder wettability, surface behavior, and formulation-relevant interactions.
Applicable pages: Physical and Chemical Properties Analysis · Bulk Powder API and Excipient Characterization
Differential Scanning Calorimetry (DSC)
Thermal method for phase transitions, melting, crystallization, desolvation, glass-transition behavior, and compatibility studies.
Applicable pages: Thermal Analysis · cGMP Thermal Analysis · Polymorphism
Disintegration Testing
Performance test used to evaluate dosage-form breakup under defined test conditions.
Applicable pages: Physical and Chemical Properties Analysis
Dissolution Testing
Performance method used to assess release behavior, formulation differences, and method-development questions.
Applicable pages: Physical and Chemical Properties Analysis
Dynamic Vapor Sorption (DVS)
Humidity-controlled sorption/desorption method for moisture uptake, hydrate risk, and water-solid interactions.
Applicable pages: Water Vapor, Karl Fischer, and DVS Analysis · Amorphous Material Development · Pharmaceutical Salts
Electron Diffraction (MicroED)
Electron-diffraction approach for structural information from microcrystalline solids and crystals too small for conventional SCXRD.
Applicable pages: Micro Electron Diffraction · Micro Electron Diffraction · Crystal Structure Determination
Energy Dispersive X-ray (EDX)
SEM-coupled elemental analysis for local elemental identification, foreign-particle analysis, and elemental mapping.
Applicable pages: Elemental Analysis · Contaminant and Impurity Analysis · Elemental Quantification
FT Raman
Raman spectroscopy configuration for molecular identification and solid-form or mixture characterization.
Applicable pages: Spectroscopy
FT-IR Infrared Spectroscopy
Infrared spectroscopy for functional-group, identity, contaminant, and material-comparison questions.
Applicable pages: Spectroscopy
Gas Chromatography
Separation method for volatile and semi-volatile organic components, impurities, residues, and related analyses.
Applicable pages: Chromatography · Mass Spectrometry · Impurity Identification
GC/MS
Gas chromatography coupled to mass spectrometry for volatile/semi-volatile identification and contaminant investigations.
Applicable pages: Mass Spectrometry · Chromatography · Unknown Contaminant Identification
Hall Flow Rate Testing
Powder-flow test used to evaluate flow rate and apparent density for powders and granular materials.
Applicable pages: Bulk Powder API and Excipient Characterization
Hot Stage Optical Microscopy
Microscopy under controlled temperature for observing melting, crystallization, phase behavior, and thermal events.
Applicable pages: Thermal Analysis · Microscopy · Polymorphism
HPLC (Liquid Chromatography)
Liquid-chromatographic separation for purity, assay, impurity, degradation, and method-development work.
Applicable pages: Chromatography · Mass Spectrometry · Impurity Identification
ICP-MS
Inductively coupled plasma mass spectrometry for trace and ultra-trace elemental analysis.
Applicable pages: Elemental Analysis · Trace Level Analysis · Elemental Quantification
Infrared Imaging
IR imaging for chemical, physical, and distribution information from small areas or heterogeneous samples.
Applicable pages: Spectroscopy
Infrared Spectroscopy
Vibrational spectroscopy for identifying organic and inorganic materials and comparing unknowns to spectral libraries.
Applicable pages: Spectroscopy
Inverse Gas Chromatography
Chromatographic technique used to probe surface and interaction properties of powders and solids.
Applicable pages: Chromatography
Karl Fischer Titration
Selective water-content method for liquids, solids, low-water samples, and oven-based insoluble-material workflows.
Applicable pages: Water Vapor, Karl Fischer, and DVS Analysis · Pharmaceutical Salts · Amorphous Material Development
LC/MS
Liquid chromatography coupled with mass spectrometry for molecular-weight confirmation, impurity/degradant ID, and trace analyses.
Applicable pages: Mass Spectrometry · LC/MS HR/MS · Impurity Identification
LC/MS/MS
Tandem mass spectrometry for targeted or high-confidence molecular analysis after chromatographic separation.
Applicable pages: Mass Spectrometry · LC/MS HR/MS · Trace Level Analysis
Low Frequency (THz) Raman
Low-frequency Raman measurement for lattice modes and solid-form discrimination.
Applicable pages: Spectroscopy
MALDI
Matrix-assisted laser desorption/ionization mass spectrometry for molecular-weight and composition questions.
Applicable pages: Mass Spectrometry
Micro Calorimetry
Sensitive heat-flow measurement for small samples, compatibility, stability, and low-level thermal processes.
Applicable pages: Thermal Analysis
Micro Electron Diffraction (MicroED)
Microcrystal electron diffraction for high-resolution structural data from nanoscale crystallites.
Applicable pages: Micro Electron Diffraction
Microtome Preparation of Samples
Sample-preparation capability for sectioning materials prior to microscopy or imaging analysis.
Applicable pages: Microscopy
NMR Spectroscopy (Solids/Liquids)
Nuclear magnetic resonance for structural identity, purity, quantitation, solid-form questions, and formulation/deformulation work.
Applicable pages: NMR Spectroscopy · cGMP NMR · Structure Elucidation NMR
Optical and Digital Microscopy
Visual and digital microscopy for particle morphology, crystal habit, contaminants, defects, and comparative imaging.
Applicable pages: Microscopy
Particle Analysis
Particle-focused testing covering size, distribution, morphology, count, charge, and related material behavior.
Applicable pages: Particle Size Analysis and Powder Characterization · cGMP Particle Size Analysis · Manufacturing Troubleshooting
Particle Charge
Assessment of charge-related particle behavior affecting flow, sticking, handling, and airborne tendency.
Applicable pages: Particle Size Analysis and Powder Characterization
Particle Distribution
Distribution measurement used to characterize powder, suspension, and particulate samples.
Applicable pages: Particle Size Analysis and Powder Characterization
Particle Size
Particle-size measurement for formulation, manufacturing, comparability, contaminant, and release-testing questions.
Applicable pages: Particle Size Analysis and Powder Characterization · cGMP Particle Size Analysis · Bulk Powder API and Excipient Characterization
pH, pKa, LogP
Physicochemical measurements used to characterize ionization, partitioning, and formulation-relevant properties.
Applicable pages: Physical and Chemical Properties Analysis
Polarimeter - Optical Rotation
Optical-rotation measurement used for chiral or identity-related physicochemical characterization.
Applicable pages: Physical and Chemical Properties Analysis
Powder Wettability Force Tensiometer
Powder wetting and surface-interaction measurement for formulation and powder-behavior studies.
Applicable pages: Bulk Powder API and Excipient Characterization
Proton Induced X-ray Emission (PIXE)
Elemental technique for multi-element analysis of solids, liquids, and aerosol filters.
Applicable pages: Elemental Analysis
Raman Imaging and Mapping
Raman-based chemical imaging for spatial location and distribution of components in heterogeneous materials.
Applicable pages: Spectroscopy · Microscopy · cGMP Raman / FTIR
SAXS (Small Angle X-Ray Scattering)
Small-angle X-ray scattering for nanoscale or microscale structure and particle-size/distribution questions.
Applicable pages: Diffraction and Crystallographic Analysis
Scanning Electron Microscopy (SEM)
Electron microscopy for surface morphology, high-magnification imaging, contaminant analysis, and SEM/EDX workflows.
Applicable pages: Microscopy · Elemental Analysis · cGMP Morphology
Single Crystal X-Ray Diffraction (SCXRD)
Single-crystal diffraction for molecular and crystal-structure determination when suitable crystals are available.
Applicable pages: Single-Crystal X-ray Diffraction · Crystal Structure Determination
Surface Analysis
Surface-focused testing for powder, particle, and material-interface questions.
Applicable pages: Bulk Powder API and Excipient Characterization
Tablet Hardness
Mechanical test used to evaluate tablet strength and dosage-form robustness.
Applicable pages: Bulk Powder API and Excipient Characterization
Tapped Density
Powder-density test used with bulk density to assess compressibility, settlement, and flow behavior.
Applicable pages: Bulk Powder API and Excipient Characterization
Thermogravimetric Analysis (TGA)
Thermal-weight-loss method for moisture/volatile content, decomposition, solvent residues, and composition.
Applicable pages: Thermal Analysis · cGMP Thermal Analysis · Water Vapor, Karl Fischer, and DVS Analysis
Unknown Identification
Investigation path for foreign materials, unknowns, counterfeit materials, contamination, failures, and OOS findings.
Applicable pages: Unknown Contaminant Identification · Root Cause Investigations · Counterfeit Analysis
UV/VIS
UV-visible spectroscopy for quantitative or kinetic measurements where absorbance response is appropriate.
Applicable pages: Spectroscopy
X-Ray Fluorescence (XRF)
Non-destructive elemental composition testing for inorganic and simple organic materials.
Applicable pages: Elemental Analysis · Elemental Quantification
XRPD - X-ray Powder Diffraction
Powder diffraction for phase identification, crystalline/non-crystalline content, polymorph work, and quantitative phase analysis.
Applicable pages: Diffraction and Crystallographic Analysis · cGMP XRPD · Polymorphism
What you receive
- Technique-selection recommendation matched to the scientific question.
- Sample, method, limitation, and complementary-technique notes.
- Data interpretation that connects instrument output to the development, quality, CMC, or IP decision.
Related services and capabilities
Common questions
Common questionsHow do I know which analytical technique to choose?
Start with the question: form, structure, impurity, contaminant, water, particle behavior, composition, release, or stability. Triclinic then selects methods that produce the evidence level required for the decision.
Is one technique enough?
Sometimes. High-impact decisions usually need orthogonal evidence because form, chemistry, water, particle behavior, and matrix effects can overlap.
Can analytical techniques be cGMP-capable?
Some methods can be used under cGMP when the method, matrix, specification, validation or transfer status, and documentation requirements support the scope.
Talk to a Triclinic Labs scientist
Send the material, current data, project objective, quality requirements, and timeline. Triclinic will route the request to the right scientific or operational contact.
